X11α impairs γ- but not β-cleavage of amyloid precursor protein
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چکیده
منابع مشابه
X11a impairs c- but not b-cleavage of amyloid precursor protein
The phosphotyrosine binding domain of the neuronal protein X11a/mint-1 binds to the C-terminus of amyloid precursor protein (APP) and inhibits catabolism to b-amyloid (Ab), but the mechanism of this effect is unclear. Coexpression of X11a or its PTB domain with APPswe inhibited secretion of Ab40 but not APPsbswe, suggesting inhibition of cbut not b-secretase. To further probe cleavage(s) inhibi...
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BACE1 cleaves the amyloid precursor protein (APP) at the β-cleavage site (Met(671) -Asp(672) ) to initiate the generation of amyloid peptide Aβ. BACE1 is also known to cleave APP at a much less well-characterized β'-cleavage site (Tyr(681) -Glu(682) ). We describe here the identification of a novel APP mutation E682K located at this β'-site in an early onset Alzheimer's disease (AD) case. Funct...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2004
ISSN: 0022-3042,1471-4159
DOI: 10.1046/j.1471-4159.2003.02234.x